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THEME INDICES

STOXX Global Breakthrough Healthcare

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Index Description

The STOXX Global Thematic indices are comprised of companies from selected markets exposed to a defined set of themes: Ageing Population, Automation & Robotics, Digitalisation, Breakthrough Healthcare. These companies operate in business areas that actively participate in social, economic and environmental changes and drive long-term structural trends. To be eligible, companies must derive 50% or more of their revenues from businesses that fall under respective themes. FactSet Revere data is used for a granular breakdown of the revenue sources of the companies in the screening process. This in turn allows enhanced precision in the thematic investment approach and in the selection of companies with substantial exposure to the targeted themes. STOXX Global Thematic indices are also taking ESG considerations into account. Companies that are non-compliant with the Global Standards Screening (GSS), involved in Controversial Weapons activities, or display a Severe (Category 5) Controversy Rating, as identified by Sustainalytics, are excluded. Additional exclusion filters are incorporated, screening companies for involvement in Weapons (Small Arms and Military Contracting), Unconventional Oil & Gas (Arctic Oil and Gas Exploration, Oil Sands and Shale Energy), Conventional Oil & Gas, Thermal Coal, Nuclear Power and Tobacco.

Key facts

  • Index allows targeted investment in Breakthrough Healthcare - a long-term structural trend
  • Based on FactSet Revere data for a detailed revenue breakdown
  • Inclusion of size and liquidity filters to ensure replicability of the index
  • Leveraging sustainability data from leading provider (Sustainalytics) to avoid exposure to companies engaged in controversial activities

Descriptive Statistics

Index Market Cap (GBP bn) Components (GBP bn) Component weight (%) Turnover (%)
Full Free-float Mean Median Largest Smallest Largest Smallest Last 12 monts
STOXX Global Breakthrough Healthcare N/A 9.7 0.1 0.0 0.2 0.0 2.1 0.0 15.7
STOXX World AC 92,745.9 71,828.1 18.3 2.6 3,760.4 0.0 5.2 0.0 2.4

Supersector weighting (top 10)

Country weighting

Risk and return figures1

Index returns Return (%) Annualized return (%)
Last month YTD 1Y 3Y 5Y Last month YTD 1Y 3Y 5Y
STOXX Global Breakthrough Healthcare 7.4 7.4 7.4 3.6 -1.5 N/A N/A 7.6 1.2 -0.3
STOXX World AC 4.7 14.2 18.4 50.7 78.9 N/A N/A 18.4 14.6 12.3
Index volatility and risk Annualized volatility (%) Annualized Sharpe ratio2
STOXX Global Breakthrough Healthcare N/A N/A 15.6 15.0 18.3 N/A N/A 0.3 -0.1 -0.1
STOXX World AC N/A N/A 14.0 12.1 13.1 N/A N/A 1.2 0.9 0.8
Index to benchmark Correlation Tracking error (%)
STOXX Global Breakthrough Healthcare 0.4 0.7 0.7 0.7 0.7 12.3 12.3 12.1 10.9 12.5
Index to benchmark Beta Annualized information ratio
STOXX Global Breakthrough Healthcare 0.6 0.7 0.7 0.9 1.0 2.3 -0.9 -1.0 -1.2 -1.0

1For information on data calculation, please refer to STOXX calculation reference guide

2Based on EURIBOR1M

(GBP, Price), all data as of October 31, 2025

THEME INDICES

STOXX Global Breakthrough Healthcare

Fundamentals

Index Price/earnings incl. negative Price/earnings excl. negative Price/book Dividend yield (%)3 Price/sales Price/cash flow
Trailing Projected Trailing Projected Trailing Trailing Trailing
STOXX Global Breakthrough Healthcare -193.7 35.3 32.1 19.2 3.9 0.8 4.3 -26.8
STOXX World AC -3.4 21.2 22.1 20.4 3.1 1.6 2.0 2.4

Performance and annual returns

Methodology

The parent index of the STOXX Global Breakthrough Healthcare Index is the STOXX Global Total Market Index. Companies, classified as belonging to a defined set of developed and emerging countries, that derive more than 50% of their most recent total annual revenue from sectors linked to the breakthrough healthcare trend are highlighted as potential index components. The index excludes companies that are not compliant with the Sustainalytics Global Standards Screening assessment or are involved in Controversial Weapons and other controversial activities. Moreover, companies that display high ESG Controversy Ratings are also excluded.

The index applies liquidity and size screens and aims to have a minimum number of 80 components. It is adjusted equal-weighted and reviewed annually in June.

Versions and symbols

Index ISIN Symbol Bloomberg Reuters
Price EUR CH0325904420 IXBRHLTE .IXBRHLTE
Net Return EUR CH0325904412 IXBRHLTT .IXBRHLTT
Gross Return EUR CH0325904404 IXBRHLTG .IXBRHLTG
Net Return USD CH0325904446 IXBRHLTU IXBRHLTU INDEX .IXBRHLTU
Gross Return USD CH0325904438 IXBRHLTS IXBRHLTS INDEX .IXBRHLTS
Price USD CH0325904453 IXBRHLTK IXBRHLTK INDEX .IXBRHLTK
Net Return GBP CH1213360238 IXBRHLTN IXBRHLTN INDEX .IXBRHLTN
Gross Return GBP CH1213360246 IXBRHLTR .IXBRHLTR
Price GBP CH1213360253 IXBRHLTP .IXBRHLTP

Quick Facts

Weighting Adjusted Equal-weighted
Cap Factor none
No. of components Min. 80
Review frequency Annual in June
Calculation/distribution Realtime 15 sec
Calculation hours 00:00:00 22:15:00
Base value/base date 1000 as of Jun. 20, 2011
History Available from Jun. 20, 2011
Inception date March. 22, 2024
To learn more about the inception date, the currency, the calculation hours and historical values, please see our data vendor code sheet.

Top 10 Components4

Company Supersector Country Weight
Illumina Inc. Healthcare USA 2.079%
Thermo Fisher Scientific Inc. Healthcare USA 2.027%
UCB Healthcare Belgium 2.020%
IQVIA HOLDINGS INC Healthcare USA 2.006%
GENMAB Healthcare Denmark 1.837%
Agilent Technologies Inc. Healthcare USA 1.798%
Johnson & Johnson Healthcare USA 1.788%
NATERA Healthcare USA 1.783%
BEONE MEDICINES Healthcare Hong Kong 1.737%
ABBVIE Healthcare USA 1.704%

3Net dividend yield is calculated as net return index return minus price index return

4Based on the composition as of October 31, 2025

CONTACT DETAILS

  • STOXX customer support
  • P +41 43 430 7272
  • customersupport@stoxx.com
  • https://stoxx.com/support/

DISCLAIMER

STOXX, Deutsche Börse Group and their licensors, research partners or data providers do not make any warranties or representations, express or implied, with respect to the timeliness, sequence, accuracy, completeness, currentness, merchantability, quality or fitness for any particular purpose of its index data and exclude any liability in connection therewith. STOXX, Deutsche Börse Group and their licensors, research partners or data providers are not providing investment advice through the publication of indices or in connection therewith. In particular, the inclusion of a company in an index, its weighting, or the exclusion of a company from an index, does not in any way reflect an opinion of STOXX, Deutsche Börse Group or their licensors, research partners or data providers on the merits of that company. Financial instruments based on the STOXX indices, DAX indices or on any other indices supported by STOXX are in no way sponsored, endorsed, sold or promoted by STOXX, Deutsche Börse Group or their licensors, research partners or data providers.

BACKTESTED PERFORMANCE

This document contains index performance data based on backtesting, i.e. calculations of how the index might have performed prior to launch if it had existed using the same index methodology and based on historical constituents. Backtested performance information is purely hypothetical and is provided in this document solely for information purposes. Backtested performance does not represent actual performance and should not be interpreted as an indication of actual performance.

CUSTOMIZATION

The index can be used as a basis for the definition of STOXX Customized Indices, which can be tailored to specific client or mandate needs. STOXX offers a wide range of customization, in terms of component selection, weighting schemes and personalized calculation methodologies.

CONTACT DETAILS

  • STOXX customer support
  • P +41 43 430 7272
  • customersupport@stoxx.com
  • https://stoxx.com/support/

DISCLAIMER

STOXX, Deutsche Börse Group and their licensors, research partners or data providers do not make any warranties or representations, express or implied, with respect to the timeliness, sequence, accuracy, completeness, currentness, merchantability, quality or fitness for any particular purpose of its index data and exclude any liability in connection therewith. STOXX, Deutsche Börse Group and their licensors, research partners or data providers are not providing investment advice through the publication of indices or in connection therewith. In particular, the inclusion of a company in an index, its weighting, or the exclusion of a company from an index, does not in any way reflect an opinion of STOXX, Deutsche Börse Group or their licensors, research partners or data providers on the merits of that company. Financial instruments based on the STOXX indices, DAX indices or on any other indices supported by STOXX are in no way sponsored, endorsed, sold or promoted by STOXX, Deutsche Börse Group or their licensors, research partners or data providers.

BACKTESTED PERFORMANCE

This document contains index performance data based on backtesting, i.e. calculations of how the index might have performed prior to launch if it had existed using the same index methodology and based on historical constituents. Backtested performance information is purely hypothetical and is provided in this document solely for information purposes. Backtested performance does not represent actual performance and should not be interpreted as an indication of actual performance.

CUSTOMIZATION

The index can be used as a basis for the definition of STOXX Customized Indices, which can be tailored to specific client or mandate needs. STOXX offers a wide range of customization, in terms of component selection, weighting schemes and personalized calculation methodologies.