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iSTOXX Developed Markets B.R.AI.N.

Index Description

Derived from the STOXX® Developed Markets Total Market Index, the iSTOXX Developed Markets B.R.AI.N. Index is comprised of companies that are exposed to four megatrends that are expected to change the world as we know it: biotechnology (B), robotics (R), artificial intelligence (AI) and nanotechnology (N). Revere (RBICS) data allow a detailed breakdown of the revenue sources of the eligible companies, helping this index to select companies with substantial exposure to the B.R.AI.N. themes.

Key facts

  • Index allows targeted investment in biotechnology, robotics, artificial intelligence and nanotechnology, four significant megatrends combined.
  • Detailed Revere data helps select companies with a revenue exposure above 50% to B.R.AI.N.-related sectors.
  • Size and liquidity filters ensure replicability.

Descriptive Statistics

Index Market Cap (EUR bn) Components (EUR bn) Component weight (%) Turnover (%)
Full Free-float Mean Median Largest Smallest Largest Smallest Last 12 monts
iSTOXX Developed Markets B.R.AI.N. N/A 9.9 0.1 0.0 0.9 0.0 9.0 0.0 25.7
STOXX Developed Markets Total Market 67,515.1 60,244.8 8.8 1.1 2,580.2 0.0 4.3 0.0 2.4

Supersector weighting (top 10)

Country weighting

Risk and return figures1

Index returns Return (%) Annualized return (%)
Last month YTD 1Y 3Y 5Y Last month YTD 1Y 3Y 5Y
iSTOXX Developed Markets B.R.AI.N. 5.0 22.2 13.2 44.3 94.3 N/A N/A 13.3 13.1 14.4
STOXX Developed Markets Total Market 5.9 14.4 6.0 32.4 65.1 N/A N/A 6.0 9.9 10.7
Index volatility and risk Annualized volatility (%) Annualized Sharpe ratio2
iSTOXX Developed Markets B.R.AI.N. N/A N/A 13.4 17.5 20.5 N/A N/A 0.9 0.7 0.7
STOXX Developed Markets Total Market N/A N/A 11.9 14.2 17.8 N/A N/A 0.5 0.6 0.6
Index to benchmark Correlation Tracking error (%)
iSTOXX Developed Markets B.R.AI.N. 0.8 0.8 0.8 0.9 0.9 7.2 7.5 7.5 9.0 9.6
Index to benchmark Beta Annualized information ratio
iSTOXX Developed Markets B.R.AI.N. 1.1 0.9 0.9 1.1 1.0 -1.4 1.0 0.9 0.3 0.3

1For information on data calculation, please refer to STOXX calculation reference guide

2Based on EURIBOR1M

(EUR, Gross Return), all data as of November 30, 2023


iSTOXX Developed Markets B.R.AI.N.


Index Price/earnings incl. negative Price/earnings excl. negative Price/book Dividend yield (%)3 Price/sales Price/cash flow
Trailing Projected Trailing Projected Trailing Trailing Trailing
iSTOXX Developed Markets B.R.AI.N. 56.8 29.8 28.3 28.3 4.0 1.5 4.7 317.9
STOXX Developed Markets Total Market -0.9 14.0 14.4 14.4 0.1 2.2 1.4 8.5

Performance and annual returns


The parent index is the STOXX Developed Markets Total Market Index.
In a first step, only stocks with a 3-month median daily traded value (MDTV) greater than EUR 1,000,000 are included. In a second step, only companies with revenue exposure above 50% to sectors associated with either one of the four B.R.AI.N. themes are included. Subsequently, these stocks are ranked according to their revenue exposure within their corresponding thematic cluster. The 20 companies with the highest exposure within each theme are included.
The index is weighted proportionally to the free-float market cap of the selected stocks multiplied by their aggregate revenue exposure to all four B.R.AI.N. themes. Weights are capped according to the following constraints: the sum of all weights above 4.5% should not exceed 35%, and no single weight should exceed 8%.
The index composition is reviewed annually. Index weighting cap factors are recalculated quarterly.

The detailed methodology including the calculation formula and the list of sectors can be found in our rulebooks:

Versions and symbols

Index ISIN Symbol Bloomberg Reuters
Gross Return EUR CH0423552451 IXBRANGR .IXBRANGR
Net Return EUR CH0423552436 IXBRANR .IXBRANR
Net Return USD CH0423552477 IXBRANV .IXBRANV
Net Return CAD CH0423552568 IXBRANU .IXBRANU

Quick Facts

Weighting Adjusted Market Cap weights
Cap Factor Single weights cannot exceed 8%. Sum of weights above 4.5% cannot exceed 35%
No. of components Variable
Review frequency Compositions reviewed annually in June. Weight factors are recalculated quarterly in March, June, September and December
Calculation/distribution dayend
Calculation hours 22:00:00 22:00:00
Base value/base date 100 as of Jun. 18, 2012
History Available Daily since Mar. 18, 2013
Inception date Jul. 26, 2018
To learn more about the inception date, the currency, the calculation hours and historical values, please see our data vendor code sheet.


iSTOXX Developed Markets B.R.AI.N.

Top 10 Components4

Company Supersector Country Weight
Intel Corp. Technology USA 9.030%
Eli Lilly & Co. Health Care USA 8.172%
ASTRAZENECA Health Care UK 7.524%
Amgen Inc. Health Care USA 7.193%
Keyence Corp. Industrial Goods and Services Japan 4.675%
Intuitive Surgical Inc. Health Care USA 4.663%
Gilead Sciences Inc. Health Care USA 4.619%
Vertex Pharmaceuticals Inc. Health Care USA 4.599%
REGENERON PHARMS. Health Care USA 4.450%
Equinix Inc. Real Estate USA 4.026%

3Net dividend yield is calculated as net return index return minus price index return

4Based on the composition as of November 30, 2023