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THEME INDICES

STOXX Global Breakthrough Healthcare

Components 1

Company Supersector Country Weight (%)
ARGENX Health Care Belgium 2.02883
Gilead Sciences Inc. Health Care USA 1.84279
UCB Health Care Belgium 1.833
SAMSUNG BIOLOGICS Health Care South Korea 1.80053
INSULET Health Care USA 1.75388
Illumina Inc. Health Care USA 1.66004
Intuitive Surgical Inc. Health Care USA 1.65392
ABBVIE Health Care USA 1.64349
Bristol-Myers Squibb Co. Health Care USA 1.63617
NATERA Health Care USA 1.61849
LONZA Health Care Switzerland 1.61622
ROCHE HLDG P Health Care Switzerland 1.60487
IQVIA HOLDINGS INC Health Care USA 1.60047
Amgen Inc. Health Care USA 1.59835
Johnson & Johnson Health Care USA 1.59347
Hologic Inc. Health Care USA 1.59048
NOVARTIS Health Care Switzerland 1.58564
EXACT SCIENCES CORP Health Care USA 1.56231
MEDTRONIC PLC Health Care USA 1.55304
Boston Scientific Corp. Health Care USA 1.54958
Celltrion Health Care South Korea 1.54557
Abbott Laboratories Health Care USA 1.5308
Thermo Fisher Scientific Inc. Health Care USA 1.51808
Agilent Technologies Inc. Health Care USA 1.51062
Pfizer Inc. Health Care USA 1.49522
Danaher Corp. Health Care USA 1.48663
SAREPTA THERAPEUTICS Health Care USA 1.4667
BIO TECHNE CORP Health Care USA 1.4507
GSK Health Care UK 1.41551
BEIGENE Health Care Hong Kong 1.34686
Eisai Co. Ltd. Health Care Japan 1.34269
GENMAB Health Care Denmark 1.34064
CATALENT Health Care USA 1.33586
CHAS.RVR.LABS.INTL. Health Care USA 1.30109
Sysmex Corp. Health Care Japan 1.26975
NEUROCRINE BIOSCIENCES Health Care USA 1.26623
Merck & Co. Inc. Health Care USA 1.26606
BIOGEN INC. Health Care USA 1.2581
QIAGEN Health Care Germany 1.2328
Shimadzu Corp. Industrial Goods and Services Japan 1.16343
Edwards Lifesciences Corp. Health Care USA 1.0943
MEDPACE HOLDINGS Health Care USA 1.03365
EXELIXIS Health Care USA 0.98729
HALOZYME THERAPEUTICS Health Care USA 0.9645
LANTHEUS HOLDINGS Health Care USA 0.92898
ZEALAND PHARMA Health Care Denmark 0.92182
REPLIGEN Health Care USA 0.919
REVOLUTION MEDICINES Health Care USA 0.91695
BIO-RAD LABORATORIES 'A' Health Care USA 0.90569
INTRA CELLULAR THERAPIES Health Care USA 0.86653
DEXCOM Health Care USA 0.85828
SARTORIUS PREF. Health Care Germany 0.79964
PRO MEDICUS Health Care Australia 0.78022
IONIS PHARMACEUTICALS Health Care USA 0.75613
BIOMERIEUX Health Care France 0.71087
MAXIMUS Industrial Goods and Services USA 0.67648
SIEGFRIED 'R' Health Care Switzerland 0.63232
MODERNA Health Care USA 0.63064
ALKERMES Health Care USA 0.58723
IPSEN Health Care France 0.55777
ASAHI INTECC Health Care Japan 0.54878
TECAN Health Care Switzerland 0.49912
DENALI THERAPEUTICS Health Care USA 0.47489
SECTRA 'B' Health Care Sweden 0.46991
NEOGEN Health Care USA 0.46595
BRIDGEBIO PHARMA Health Care USA 0.46373
AXSOME THERAPEUTICS Health Care USA 0.43627
AKESO Health Care Hong Kong 0.43545
TG THERAPEUTICS Health Care USA 0.41585
EVOLENT HEALTH CL.A Health Care USA 0.40603
AXONICS Health Care USA 0.39865
CORVEL Health Care USA 0.38807
GUARDANT HEALTH Health Care USA 0.37491
DIASORIN Health Care Italy 0.36911
TANDEM DIABETES CARE Health Care USA 0.3587
ARCELLX Health Care USA 0.35653
RHYTHM PHARMACEUTICALS Health Care USA 0.35105
R1 RCM Health Care USA 0.34885
BAVARIAN NORDIC Health Care Denmark 0.34773
PTC THERAPEUTICS Health Care USA 0.34079
LIVANOVA Health Care USA 0.33696
BACHEM HOLDING Health Care Switzerland 0.33063
MERUS NV Health Care USA 0.3211
IDEAYA BIOSCIENCES Health Care USA 0.31791
GERON Health Care USA 0.31526
TWIST BIOSCIENCE Health Care USA 0.30602
VERACYTE Health Care USA 0.30481
MYRIAD GENETICS Health Care USA 0.30161
CATALYST PHARMACEUTICAL PRTNRS Health Care USA 0.30125
ELEKTA B Health Care Sweden 0.29259
10X GENOMICS A Health Care USA 0.29114
SK BIOPHARMACEUTICALS Health Care South Korea 0.2844
QUIDELORTHO Health Care USA 0.2796
IOVANCE BIOTHERAPEUTICS Health Care USA 0.27834
ASTRANA HEALTH Health Care USA 0.27033
FORTREA HOLDINGS Health Care USA 0.26158
ACADIA PHARMACEUTICALS Health Care USA 0.24625
JEOL Industrial Goods and Services Japan 0.24419
HUTCHMED CHINA (HKG) Health Care Hong Kong 0.23183
SAWAI GRP. HLDGS. Health Care Japan 0.2304
H. LUNDBECK B Health Care Denmark 0.22692
BEAM THERAPEUTICS Health Care USA 0.22157
LIGAND PHARMS.'B' Health Care USA 0.22092
JANUX THERAPEUTICS Health Care USA 0.21831
SUPERNUS PHARMACEUTICALS Health Care USA 0.21426
NOVOCURE Health Care USA 0.21144
BIOCRYST PHARMS. Health Care USA 0.20472
ARVINAS Health Care USA 0.20076
CAREDX Health Care USA 0.18136
DYNAVAX TECHNOLOGIES Health Care USA 0.18082
HARMONY BIOSCIENCES HLDG Health Care USA 0.18014
NOVAVAX Health Care USA 0.17868
ATRICURE Health Care USA 0.16952
OXFORD NANOPORE TECHNOLOGIES Health Care UK 0.163
XENCOR Health Care USA 0.15809
XVIVO PERFUSION Health Care Sweden 0.15607
NEUREN PHARMACEUTICALS Health Care Australia 0.15416
CERTARA Health Care USA 0.15285
INTEGRA LFSC.HDG. Health Care USA 0.14572
PROTHENA Health Care USA 0.14294
RECURSION PHARMACEUTICALS A Health Care USA 0.14255
SCHRODINGER Technology USA 0.14182
GALAPAGOS Health Care Belgium 0.13788
CHEMOMETEC Health Care Denmark 0.13779
UNITED LABS.INTL.HDG. Health Care Hong Kong 0.13544
SK BIOSCIENCE Health Care South Korea 0.12327
EVOTEC Health Care Germany 0.12256
AURINIA PHARMS. (NAS) Health Care USA 0.12
RELAY THERAPEUTICS Health Care USA 0.11782
MARAVAI LIFESCIENCES HLDS A Health Care USA 0.11483
ST PHARM Health Care South Korea 0.11106
ABL BIO Health Care South Korea 0.1076
KEYMED BIOSCIENCES Health Care Hong Kong 0.10443
CASTLE BIOSCIENCES Health Care USA 0.10438
LUNIT Health Care South Korea 0.10249
ZYMEWORKS Health Care USA 0.10204
VIR BIOTECHNOLOGY Health Care USA 0.10027
Seegene Health Care South Korea 0.09966
PEPTRON Health Care South Korea 0.09533
AVID BIOSERVICES Health Care USA 0.09041
PHARMA MAR Health Care Spain 0.08821
CYTEK BIOSCIENCES Health Care USA 0.08504
ADAPTIVE BIOTECHNOLOGIES Health Care USA 0.08297
ARCUS BIOSCIENCES Health Care USA 0.08293
IMMUNITYBIO Health Care USA 0.08183
BIOARCTIC B Health Care Sweden 0.08089
ANAPTYSBIO Health Care USA 0.08045
POLARIS GROUP Health Care Taiwan 0.07576
DYNAVOX Technology Sweden 0.07474
EIKEN CHEMICAL Health Care Japan 0.07297
ROCHE HLDG BEARER Health Care Switzerland 0.07172
ABCELLERA BIOLOGICS Health Care USA 0.07043
AXOGEN Health Care USA 0.07007
4D MOLECULAR THERAPEUTICS Health Care USA 0.06608
QUANTERIX Health Care USA 0.06356
PHARMING GROUP Health Care Netherlands 0.06318
Y MABS THERAPEUTICS Health Care USA 0.06301
PACIFIC BSCS.OF CAL. Health Care USA 0.06016
SIMULATIONS PLUS Technology USA 0.05873
ARCTURUS THERAPEUTICS HOLDINGS Health Care USA 0.05765
JAPAN LIFELINE Health Care Japan 0.057
REGENXBIO Health Care USA 0.05559
ALECTOR Health Care USA 0.05358
ITEOS THERAPEUTICS Health Care USA 0.04966
SAGE THERAPEUTICS Health Care USA 0.04957
COMPUGROUP MEDICAL Health Care Germany 0.04879
SD BIOSENSOR Health Care South Korea 0.04864
STOKE THERAPEUTICS Health Care USA 0.04775
FATE THERAPEUTICS Health Care USA 0.04703
UROGEN PHARMA Health Care USA 0.04455
SHIN POONG PHARM. Health Care South Korea 0.04365
ALLOGENE THERAPEUTICS Health Care USA 0.0416
TAKARA BIO Health Care Japan 0.04109
ORASURE TECHS. Health Care USA 0.03922
ACCOLADE Health Care USA 0.03528
VALNEVA Health Care France 0.03324
VANDA PHARMACEUTICALS Health Care USA 0.03269
MERSANA THERAPEUTICS Health Care USA 0.0321
LYELL IMMUNOPHARMA Health Care USA 0.03171
UNIQURE Health Care USA 0.02997
SILLAJEN Health Care South Korea 0.02995
PHC HOLDINGS Health Care Japan 0.02913
I-SENS Health Care South Korea 0.02875
REMEGEN 'H' Health Care China 0.02864
SUTRO BIOPHARMA Health Care USA 0.02657
NEVRO Health Care USA 0.02615
SH JUNSHI BIOSCIENCES 'H' Health Care China 0.02509
IDORSIA LIMITED Health Care Switzerland 0.02468
ATAI LIFE SCIENCES N V Health Care USA 0.02346
MACROGENICS Health Care USA 0.02306
CARIBOU BIOSCIENCES Health Care USA 0.02129
AGENUS Health Care USA 0.01255
1Based on the last periodic review implementation